Health Condition 1: null- Squamous Cell Carcinoma of Head & Neck
Conditions
Interventions
Intervention1: NA: NA
Sponsors
Prince Aly Khan Hospital
Eligibility
Inclusion criteria
Inclusion criteria: 1.Pathologically (histologically or cytologically) proven AJCC/TNM staged diagnosis of squamous cell carcinoma of the oral cavity, oropharynx, larynx, or hypopharynx (excluding lip, nasopharynx, or sinuses) 2.Zubrod Performance Status 0-1 3.Age 18years and above 4Patient must sign a study-specific informed consent prior to study entry, which includes mandatory submission of tissue for HPV analysis
Exclusion criteria
Exclusion criteria: 1. Evidence of distant metastases or simultaneous primaries 2. Prior invasive malignancy (except non-melanomatous skin cancer) unless disease free for a minimum of 3 years with the exception of cervical carcinoma in situ and adequately treated basal cell or squamous cell carcinoma of the skin or untreated/treated low-risk prostate cancer(defined as clinical or pathologic T1c, N0 M0, PSA 10, Gleason 7, 50% of the total cores positive for cancer); 3. Prior systemic chemotherapy for the study cancer; note that prior chemotherapy for a different cancer is allowable. 4. Prior radiotherapy to the head and neck area that would result in overlap of radiation therapy fields.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The prevalence of HPV infection in oral, oropharyngeal, laryngeal and hypo pharyngeal cancersTimepoint: At diagnosis | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation of HPV prevalence and Locoregional control and survival at 3 yearsTimepoint: Effect of Treatment in HPV positive cases with patient follow up till 3 years | — |
Countries
India
Contacts
Public ContactDr Sharmila Agarwal
Prince Aly Khan Hospital
Outcome results
None listed