Randomised Double Blind Controlled Trial of Minocycline in Japanese encephalitis

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2010/091/006143

Enrollment

144

Registered

2011-01-11

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Minocycline: 5 mg/kg followed by 2.5 mg/kg 12 hourly for 7 dauys

200 mg followed by 100 mg 12 hourly in adults Control Intervention1: Placebo: same as for drug

Eligibility

Inclusion criteria

Inclusion criteria: Children > 3 years old and adults with suspected encephalitis

Exclusion criteria

Exclusion criteria: women of child bearing age (16-44 years)

Design outcomes

Primary

Measure	Time frame
Cumulative Mortality at 3 months from onsetTimepoint: 3 months	—

Secondary

Measure	Time frame
? Number of days since randomization for fever to subside. ? Number of days since randomization to come to oral feeding ? Number of days since randomization to return to full consciousness (Glasgow Coma Scale of 15) ? Number of days in hospital since randomization ? Neurological deficits or abnormalities of tone or posture or movement at discharge. ? Neurologic deficits, frank mental retardation or other symptoms such as epilepsy at follow up at 6 months Timepoint: 3 months	—

Measure

Time frame

? Number of days since randomization for fever to subside. ? Number of days since randomization to come to oral feeding ? Number of days since randomization to return to full consciousness (Glasgow Coma Scale of 15) ? Number of days in hospital since randomization ? Neurological deficits or abnormalities of tone or posture or movement at discharge. ? Neurologic deficits, frank mental retardation or other symptoms such as epilepsy at follow up at 6 months Timepoint: 3 months

—

Countries

India

Contacts

Public ContactRashmi Kumar

rashmik2005@gmail.com0522-2322577

Outcome results