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Role of new diagnostic test i.e. Interferon Gamma Release Assay (IGRA)in diagnosis and prognosis of tuberculous meningitis patients

MTB complex Interferon Gamma Release Assay (IGRA) in blood and CSF of Tuberculous meningitis patients

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2010/091/003048
Enrollment
40
Registered
2010-12-07
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: NIL: NIL Control Intervention1: NIL: NIL

Sponsors

NIL
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Fever, headache, meningismus, other signs and clinical presentations of meningitis of more than 2 weeks duration. 2. Typical cerebrospinal fluid (CSF) features including pleocytosis with more than 20 cells, lymphocytes greater than 60%, protein greater than 100mg% and glucose level less than 60% of the corresponding blood glucose level. Presumptive diagnosis of TBM will be made based on the clinical criteria with typical CSF features and at least one of the following supporting criteria: 1. Radiographic findings based on chest X-ray that confirmed pulmonary TB (reticulonodular pattern in upper lobes with or without cavitatory lesions), 2. Hydrocephalous from brain computerized tomography (CT) scan, 3. Response to anti-tuberculous treatment after 4 weeks.

Exclusion criteria

Exclusion criteria: 1. The patients who already received more than 30 days of antituberculous drugs and steroids. 2. The patient declined to give consent.

Design outcomes

Primary

MeasureTime frame
Death or severe disability assessed by modified Rankin scaleTimepoint:

Secondary

MeasureTime frame
NILTimepoint: NIL

Countries

India

Contacts

Public ContactVidhate Mukund Ramrao

Senior resident

drmukundvidhate@yahoo.co.in02532531658

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026