Chemo- radiotherapy of cancer of cheek with Tomotherapy .

A Phase II trial of Tomotherapy for locally advanced buccal mucosa tumors as a method of dose escalation.

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2010/091/002920

Enrollment

Registered

2010-11-10

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Locally advanced inoperable/ unresctable carcinoma of Buccual Mucosa

Interventions

Intervention1: Helical Tomotherapy: 70.2 Gy in 30 fraction to GTV (2.34Gy/Fr) Control Intervention1: NIL: NIL

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients with unresectable /inoperable buccal mucosa cancer. 2.Histologic confirmation of squamous cell carcinoma. 3.Stage IV tumors (T4b/N0-3 disease) 4.Patient willing and reliable for follow up.

Exclusion criteria

Exclusion criteria: 1.KPS<70 2.Age>70 years 3.Life expectancy <6 mths 4.Gross involvement of bone 5.Prior radiotherapy to head and neck region 6.Any other malignancyin any other site (except non squamous skin cancers) 7.Severe co-morbid conditions (severe cardiac disorder, severe bronchial asthama, psychological disorder)

Design outcomes

Primary

Measure	Time frame
1.Assess feasibility of dose escalation in locally advanced inoperable buccal mucosa cancer. 2.Toxicity profile 3.Assess response to treatment and survival parameters with higher dose of radiation.Timepoint: None	—

Secondary

Measure	Time frame
NILTimepoint: NIL	—

Countries

India

Contacts

Public ContactDr JP Agarwal

agarwaljp@tmc.gov.in02224177164

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026