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EFFICACY OF INTRA-ARTICULAR TRANEXAMIC ACID IN PRIMARY UNILATERAL TOTAL KNEE ARTHROPLASTY: A PRELIMINARY STUDY

EFFICACY OF INTRA-ARTICULAR TRANEXAEMIC ACID TO REDUCE POST OPERATIVE BLOOD LOSS IN PRIMARY UNILATERAL TOTAL KNEE REPLACEMENT.

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2010/091/001260
Enrollment
90
Registered
2010-11-08
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Administration of tranexamic acid (Antifibrinolytic): 500mg/5ml single dose, intra-articular after wound closure of total knee arthroplasty and clamping of drain for an hour Control Int
Normal saline: 5 ml, single dose, intra-articular after wound closure of total knee arthroplasty and clamping of drain for an hour Control Intervention2: control-2
no placebo: no drain clamping

Sponsors

Dr. O. N. Nagi, Chairman, Joint Replacement and Reconstruction Unit, Sir Ganga Ram Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients diagnosed with osteoarthritis scheduled for unilateral cemented TKA, either sex, aged <80 years

Exclusion criteria

Exclusion criteria: Patients with known allergy to tranexamic acid, hepatic/cardio-respiratory/renal insufficiency, congenital or acquired coagulopathy, recent history of thrombo-embolic episode

Design outcomes

Primary

MeasureTime frame
Blood Loss, measured by drain output drop in Hb and PCVTimepoint: up to 5th day after surgery—

Secondary

MeasureTime frame
Requirement of blood transfussionTimepoint: Course of inpatient stay after total knee arthroplasty—

Countries

India

Contacts

Public ContactDr. O.N.Nagi

Orthopedic Junior resident

umairtanki@gmail.com09717046333

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026