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A prospective study to determine the prevalence of HCV infection among family members of HCV infected patients and also to analyze Intrafamilial correlations in Hepatitis C Virus (HCV).

A prospective, single region, seroprevalence study within families of index patients to analyze intrafamilial correlations in Hepatitis C virus. Acronym- FACT-C

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2010/091/001231
Enrollment
100
Registered
2010-10-08
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Nil: Nil Control Intervention1: Nil: Nil

Sponsors

Investigator sponsored Dr. Ajit Sood
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Index patients with serologically confirmed Hepatitis-C viral infection 2. Family members of Index Patients with age above 5 years, staying together in same house 3. Written informed consent from adult family members (age ≥ 18 years) and assent from pediatric members in addition for participation in the study 4. Control Patients with serological evidence of Hepatitis C without any family members infected with Hepatitis C 5. Willing to provide feedback on questionnaire for identifying risk factors 6. Willing to provide blood sample for serological analysis and other laboratory analysis

Exclusion criteria

Exclusion criteria: 1. Index Patients, their Family members and Control patients who have been treated with Interferon based therapy and already cleared of virus.

Design outcomes

Primary

MeasureTime frame
1. To evaluate the Genotype and HCV sequencing (Phylogenetic analysis) of the virus affecting the family members 2. To determine the prevalence of HCV infection among family members of Index patients with HCV infection Timepoint: 4 Months for field visits, completion of questionnaire and collection of samples / results.—

Secondary

MeasureTime frame
1. To identify the factors responsible for intrafamilial spread of HCV infection. 2. To determine phylogenetic similarity between Index patients and their infected Neighbours with no evidence of familial prevalence Timepoint: 4 Months for field visits, completion of questionnaire and collection of samples / results—

Countries

India

Contacts

Public ContactDr. Ajit Sood
ajitsood10@sifymail.com01612301749

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026