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An innovative regenerative technique to heal infected, mature teeth without root canal filling

A new endodontic protocol of inducing natural apical seal (Bio-Seal) and healing of pulp and periapically involved teeth.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2010/091/001030
Enrollment
15
Registered
2010-06-28
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Innovative non-obturation Endodontic technique: After control of intra canal infection by chemo-mechanical means, indigenous stem cells residing in the periapical area of teeth being tr

Sponsors

AIIMS
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Cases presenting with clinical or radiographic signs and symptoms of periapical pathologies, irrespective of age and sex will be included in the study

Exclusion criteria

Exclusion criteria: Patients having any systemic disease, which can compromise the healing response such as diabetes, patients on excessive medications, on immuno-suppressants, those receiving RT or CT etc. will not be included.

Design outcomes

Primary

MeasureTime frame
Complete control and resolution of clinical signs and symptoms of periapical disease, such as pain, swelling, inflammation and restoration of function Radiographic evidence of healing of periapical lesions showing disappearance or reduction in size of the lesion or atleast arrest of lesion size (not increasing) Timepoint: Follow-up at 3,6,12,18 and 24 months

Secondary

MeasureTime frame
Formation of a natural, biological seal of mineralized tissue at the root apicesTimepoint: Follow-up at 3,6,12,18 and 24 months

Countries

India

Contacts

Public ContactDr. Naseem Shah

AIIMS

nasemys@gmail.com91-11 26589304

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026