None listed
Conditions
Interventions
Intervention1: Autologous MNCs CD-34+AND CD 45+ CELLS:
Control Intervention1: NIL: NIL
Sponsors
Global Medical Education and research centre
Eligibility
Inclusion criteria
Inclusion criteria: Ages Eligible for Study: >21 Years Genders Eligible for Study: Both Accepts Healthy Volunteers: No External angina class III ? IV. Severe LV systolic dysfunction with EF ≤ 30% Single/Multi vessel coronary artery disease with diffuse atherosclerotic disease neither suitable for (CADGS) bypass grafting nor for percutaneous intervention (PTCA + Stenting). ?Hypokinetic, Akinetic, Dyskinetic segments assessed by 16 segments Echo model.
Exclusion criteria
Exclusion criteria: ? LVEF ≤ 31%. ? Severe hepatic or renal dysfunction (Co-morbid Medical condition). ? Stroke with significant sequel. ? HIV/HBS/HCV positive serology. ? Short life expectancy due to cancer/ terminal illness which influence the patient. ? Mental disorders. ? Possibility of non-compliance with the protocol. ? Gross CCF/Pulmonary edema.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ? Improvement in LVEF perfusion measured by ECG, 2D-ECHO, Cardiac MRI Coronary angiography.Timepoint: 12 months | — |
Secondary
| Measure | Time frame |
|---|---|
| ? Safety ? Improvement in myocardial function observed in SA node, AV node measured by ECG. ? Improved exercise time when observed on the 3rd and 6th month after the therapeutic procedure, when compare to exercise time before the administration of the therapeutic dose. ? Improvement in physical activity (Mild to Moderate), (Rest or Minimal to Mild). ? Reduction in the use of medicines Timepoint: 12 months | — |
Countries
India
Contacts
Public ContactDr.Smita Gheyee
Co-Investigator
Outcome results
None listed