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A clinical trial to compare the effects of two anaesthetic drugs- desflurane and isoflurane in patients undergoing elective neurosurgery.

A prospective, randomized, double-blinded study comparing the effects of Desflurane and Isoflurane on emergence from anaesthesia and recovery of post-operative motor deficits in patients undergoing elective neurosurgery for supratentorial mass lesions.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2010/091/000616
Enrollment
60
Registered
2010-08-06
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Desflurane: 0.8 MAC Control Intervention1: Isoflurane: 0.8 MAC

Sponsors

Dr Aparanjit Paul
Lead Sponsor
Department of Anaesthesiology and Neurological Sciences
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: a) Elective neurosurgical patients with supratentorial intra-axial mass lesions b) Age 18 -75 years c) ASA grade I - III d) Pre-operative GCS ? 15/15

Exclusion criteria

Exclusion criteria: a) Previous craniotomy b) Hepatic or renal disease (elevated SGOT/SGPT/ALP/creatinine) c) Alcohol or drug abuse d) Hypothyroidism? any thyroid function test outside normal limits e) BMI > 35 f) Midline shift > 5mm on CT/MRI g) Female patients ? pregnant/breastfeeding

Design outcomes

Primary

MeasureTime frame
i. Time to obeying motor commands ii. Time to extubation iii. Time to eye opening iv. Time to orientation v. Time to recovery of motor deficits Timepoint: i-iv. At end of surgery v. withing 12 hours after surgery—

Secondary

MeasureTime frame
I. Brain Relaxation Score II. Number Of Episodes Of : Hypotension(MAP < 20% Baseline), Hypertension(MAP>20% Baseline) And Bradycardia (Heart Rate <45bpm) Timepoint: During the surgery—

Countries

India

Contacts

Public ContactDr Aparanjit Paul

None

grace.korula@gmail.com04162282105

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026