None listed
Conditions
Interventions
Intervention1: scorpion antivenom: 30 ML intravenous route
Control Intervention1: prazosin + scorpion antivenom: prazosin 250 microgram in children and 500 microgram in adult repeated 3 hourly interv
Sponsors
Nil
Eligibility
Inclusion criteria
Inclusion criteria: Patients were eligible for enrollment if they reported to hospital with MT scorpion bite, with grade II, with an interval less than 6 hours between scorpion bite and hospitalization; age > 6 months. MT scorpion bite was confirmed if patient have seen red scorpion or brought the killed specimen or confirmed by showing him the hospital preserved specimen or photograph
Exclusion criteria
Exclusion criteria: Major exclusion criteria were, patient reporting after six hours of sting, pregnant women, previous history of taking prazosin or scorpion Antivenom, patient with history of bronchial asthma or previous history of allergic reaction to foreign serum and who refused to give consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ABSTRACT Objective- To evaluate the efficacy and safety of prazosin and prazosin with scorpion anti-venom combination in victims of envenomation by venomous scorpion ( Mesobuthus Tamulus ). Design ? Randomized open label trial Setting- Bawaskar Hospital and research Center Mahad Dist-Raigad Maharashtra India 402301 Participants- 70 patients with scorpion sting Grade II Intervention- We did an open ?label , randomized , controlled trial of scorpion anti-venom(SAV)+ prazosin versus prazosin alone for scorpion sting victims at general hospital. We compared the effectiveness of two regimens by assessing the clinical resolution of syndrome within 10 hours. 70 cases of scorpion sting of grade category were assigned to SAV+prazosin(n=35) or prazosin (n=35) by block randomization. The trial was registered with study protocol was approved by the independent Ethical Committee Mumbai Regd. No. 1433/1999 G.B.B.SD ( IEC/08/39). Main outcome measures. Patients from SAV +prazosin group recovered earlier (Mean [95%CI;8 hours6.5-9.5] as compared to prazosin treated patients (17.7 hours [15.4-19-9] ; t-test, p<0.001;( mean difference -9.7 hours[95% CI-6.9 to -12.4]. Number of cases deterioration to higher grade was similar in SAV+prazosin(4/35) and only prazosin(5/35); p<0.99. hypotension was reported in less number of patients(12/35,34.3% from SAV+prazosin than those treated with prazosin(19/35,54.3%), but it was statistically significant ;p=0.092. No difference was noted in change in blood pressure and pulse rate overtime between two groups.. Conclusion- We found clinically recovery is hastened by simultaneous administration of scorpion antivenom plus prazosin alone. Timepoint: resoluion of clnical syndrome at the end of ten hours of admission in both arm prazoisn +scorpion nativenom and Prazosin alone | — |
Secondary
| Measure | Time frame |
|---|---|
| Total dose of prazosin required , hypotension and deterortaion to higher gradesTimepoint: within 10 hours of administration of trila regimen prazosin + scorpion antivenom | — |
Countries
India
Contacts
Public ContactDr Raakhi Tripathi
Outcome results
None listed