Health Condition 1: E871- Hypo-osmolality and hyponatremia Health Condition 2: R69- Illness, unspecified
Conditions
Interventions
Intervention1: Isotonic Saline Solution (0.9% NaCl Solution In 5% Dextrose): 60% Of The Maintenance Fluid Requirement (Calculated By Holiday And Segar Formula) for 48 hours
Control Intervention1: Hypo
Sponsors
Jawaharlal Nehru Medical College
Eligibility
Inclusion criteria
Inclusion criteria: Children in the age group of 0.5 to 12 years who are admitted and anticipated to receive intravenous fluid for the next 48 hours
Exclusion criteria
Exclusion criteria: 1)Baseline serum sodium concentration less than 130 mmol/L or greater than 150 mmol/L 2)Hemodynamically unstable patients: shock, myocarditis, congestive heart failure 3)Acute gastroenteritis with dehydration 4)If intravenous fluid has been administered within the 3 hours preceding the study 5)Acute or chronic kidney disease, a history/evidence of cardiac dysfunction, severe chronic neurological illnesses (uncontrolled seizure disorders, severe developmental delay), diabetes mellitus or insipidus 6)Pre-existing hypertension, diuretic use, edema, or known adrenal dysfunction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of hyponatremiaTimepoint: 24 and 48 hours after initiating intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood: sodium,potassium, chloride, pH, urea, serum creatinine. Urine output,weightTimepoint: 12 hourly;Manifestations attributable to dysnatremias,Case fatality rateTimepoint: During the study observation period;Serum osmolalityTimepoint: 24 hourly | — |
Countries
India
Contacts
Public ContactDr. Kamran Afzal
Reader, Department of Pediatrics
Outcome results
None listed