Does monitoring depth of anesthesia with entropy (EEG derived parameter) decrease isoflurane concentration and recovery time from anesthesia in children undergoing day care surgery?

Entropy monitoring decreases isoflurane concentration and recovery time in pediatric day care surgery

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2010/091/000318

Enrollment

Registered

2010-04-21

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: PCS- Health Condition 2: M00-M99- Diseases of the musculoskeletal system and connective tissue Health Condition 3: null- Pediatric patients undergoing day care surgery e.g hernias,urethroplasties, orchidopexies etc.

Interventions

Intervention1: Entropy monitoring: monitoring depth of anesthesia with an EEG based entropy monitor. Intervention2: Entropy monitoring: monitoring depth of anesthesia with an EEG based entropy monitor

Eligibility

Inclusion criteria

Inclusion criteria: 50 ASA grade I and II children, aged 2-12 years, scheduled for lower abdominal and urological surgery on day care basis were enrolled in the study

Exclusion criteria

Exclusion criteria: Children whose parents refused consent, those with known neurological disorders, with history of major head injury, on antiepileptic drugs, or having any contraindications to laryngeal mask airway (LMA) insertion were excluded from the study

Design outcomes

Primary

Measure	Time frame
The primary aim of this study was to evaluate whether entropy monitoring would result in faster awakening at the end of surgery in children undergoing day care procedures under general anesthesia.Timepoint: Time to awakening from anesthesia after swiching off of the inhalation agent at the end of surgery;The primary aim of this study was to evaluate whether entropy monitoring would result in faster awakening at the end of surgery in children undergoing day care procedures under general anesthesia.Timepoint: Time to awakening from anesthesia after swiching off of the inhalation agent at the end of surgery	—

Measure

Time frame

The primary aim of this study was to evaluate whether entropy monitoring would result in faster awakening at the end of surgery in children undergoing day care procedures under general anesthesia.Timepoint: Time to awakening from anesthesia after swiching off of the inhalation agent at the end of surgery;The primary aim of this study was to evaluate whether entropy monitoring would result in faster awakening at the end of surgery in children undergoing day care procedures under general anesthesia.Timepoint: Time to awakening from anesthesia after swiching off of the inhalation agent at the end of surgery

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Secondary

Measure	Time frame
To compare the intraoperative end tidal isoflurane concentrations, hemodynamic parameters and perioperative analgesic requirement between the two groups.Timepoint: The electrocardiogram (ECG), noninvasive blood pressure (NIBP), oxygen saturation (SpO2) and end tidal carbon dioxide (EtCO2), end tidal concentration of isoflurane (Et iso), State Entropy and Response Entropy were monitored throughout the surgery (Datex Ohmeda S/5 Avance).;To compare the intraoperative end tidal isoflurane concentrations, hemodynamic parameters and perioperative analgesic requirement between the two groups.Timepoint: The electrocardiogram (ECG), noninvasive blood pressure (NIBP), oxygen saturation (SpO2) and end tidal carbon dioxide (EtCO2), end tidal concentration of isoflurane (Et iso), State Entropy and Response Entropy were monitored throughout the surgery (Datex Ohmeda S/5 Avance).	—

Measure

Time frame

To compare the intraoperative end tidal isoflurane concentrations, hemodynamic parameters and perioperative analgesic requirement between the two groups.Timepoint: The electrocardiogram (ECG), noninvasive blood pressure (NIBP), oxygen saturation (SpO2) and end tidal carbon dioxide (EtCO2), end tidal concentration of isoflurane (Et iso), State Entropy and Response Entropy were monitored throughout the surgery (Datex Ohmeda S/5 Avance).;To compare the intraoperative end tidal isoflurane concentrations, hemodynamic parameters and perioperative analgesic requirement between the two groups.Timepoint: The electrocardiogram (ECG), noninvasive blood pressure (NIBP), oxygen saturation (SpO2) and end tidal carbon dioxide (EtCO2), end tidal concentration of isoflurane (Et iso), State Entropy and Response Entropy were monitored throughout the surgery (Datex Ohmeda S/5 Avance).

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Countries

India

Contacts

Public ContactAnjolie Chhabra

All India Institute of Medical Sciences, Ansari Nagar, N Delhi

anjolie5@hotmail+91-11-25220616

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026