A CLINICAL TRIAL TO STUDY THE EFFECTS OF TREATMENT WITH THYROID HORMONE IN WOMEN WITH HISTORY OF BLIGHTED OVUM AND POSITIVE ANTI-THYROID ANTIBODIES.

ANTI-THYROID ANTIBODIES AND THYROID HORMONE REPLACEMENT IN WOMEN WITH THE HISTORY OF CHROMOSOMALLY COMPETENT BLIGHTED OVUM.

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2010/091/000106

Enrollment

Registered

2010-02-18

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Thyroid status and autoimmunity: Tab Levothyroxin 50 mcg daily for two weeks then 100 mcg daily to continue in presence of TSH more than 2.5 mcu/ml and in presence of autoimmunity, even

Eligibility

Inclusion criteria

Inclusion criteria: women having the history of blighted ovum (detected by USG) but chromosomally competent conceptus, will be tested for thyroid status and thyroid autoimmunity.

Exclusion criteria

Exclusion criteria: 1.Any abortion other than blighted ovum, detected sonographically. 2.Women already on thyroid hormone replacement or taking corticosteroids for any reason.

Design outcomes

Primary

Measure	Time frame
1. prevalence of thyroid autoimmunity in chromosomally competent conception but blighted ovum 2.Success in subsequent pregnancy with thyroid hormone replacement in presence of thyroid autoimmunity, even if the TSH level is below 2.5 miu/ml.Timepoint: No fixed time point for assessment. Women will be assessed in subsequent pregnancy after getting thyroid hormone treatment.	—

Secondary

Measure	Time frame
failure to have a successful outcome even with thyroid hormone replacement in adequate doses in presence of thyroid autoimmunityTimepoint: No fixed time point. Women will be assessed in subsequent pregnancy.	—

Countries

India

Contacts

Public ContactDR.SUDHINDRA MOHAN BHATTACHARYA

CONSULTANT; VISITING SURGEON. DEPT. OF OBSTETRICS AND GYNAECOLOGY

drsudhindra54@gmail.com033-24836330

Outcome results