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A clinical trial to study the effect of n-acetylcysteine on endothelial dysfunction,oxidative stress and carotid artery intimal thickness in chronic dialysis patients.

Effect of N-Acetylcysteine on Oxidative Stress, Endothelial Dysfunction and Carotid Artery Intimal Thickness in Chronic Peritoneal Dialysis Patients -An Open Labeled Randomized Trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2010/091/000090
Enrollment
100
Registered
2010-06-28
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: N-acetylcysteine: 600 mg twice daily Control Intervention1: Nil: Nil

Sponsors

Nil
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Stable CAPD/CCPD patients of either gender on therapy for a minimum period of three months 2. Age between 18 yrs to 60 yrs

Exclusion criteria

Exclusion criteria: 1. Smokers 2. Recent episode of peritonitis (within 6 weeks of study) 3. Should not be on antioxidants in 2 months before the study enrolment 4. Presence of malignancy, autoimmune disease or chronic liver disease, active infection 5. Known hypersensitivity to NAC/GTN

Design outcomes

Primary

MeasureTime frame
? To study carotid intimal medial thickness, oxidative stress, endothelial dysfunction and inflammatory markers in stable chronic peritoneal dialysis patients ? To look at co-relation if any between these parameters Timepoint: one year—

Secondary

MeasureTime frame
? To evaluate the effect of six months therapy of oral N-acetyl cysteine on the above parametersTimepoint: one year—

Countries

India

Contacts

Public ContactDr Mitul Bora
boramitul@rediffmail.com01126594817

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026