study to determine requirement of anesthesia in diabetic patients compared to healthy patients

Comparison of the requirement of isoflurane and vecuronium in diabetic patients with and without diabetic autonomic neuropathy undergoing elective surgery; as determined by entropy and NMT monitor respectively- A prospective double blind study

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Observational

Source

CTRI

Registry ID

CTRI/2010/091/000040

Enrollment

Registered

2010-07-20

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical Health Condition 2: null- To determine requirement of isoflurane and vecuronium in diabetic patients with or without autonomic neuropathy undergoing elective surgery.

Interventions

Intervention1: anesthetic titration: guided by entropy and NMT Control Intervention1: Nil: Nil

Eligibility

Inclusion criteria

Inclusion criteria: ASA physical status I or II Age 18-60 years Controlled diabetic patients of > 3 years duration;HbA1C >8

Exclusion criteria

Exclusion criteria: BMI>28 Any neuromusular disease Pregnancy Predicted difficult airway with laryngoscopic tome > 15 secs History of liver or renal disease History of alcohol or drug abuseHistory of gastric esophageal reflux disease High blood pressure or the use of beta blocking agent Hypersensitivity to any of the frugs to be used

Design outcomes

Primary

Measure	Time frame
Amount of Isoflurane required to maintain SE between 40-60 by measuring isoflurane vaporizer before and after anesthesia The minimum to maximum amount of MAC isoflurane required to maintain SE between 40-60 Total consumption of vecuronium and fentanyl Total intraoperative consumption of atropine and ephedrine Comparison of the amount of isoflurane and vecuronium consumed in both the groups Timepoint: Preoperative At the time of induction Intraoperative Postoperative	—

Measure

Time frame

Amount of Isoflurane required to maintain SE between 40-60 by measuring isoflurane vaporizer before and after anesthesia The minimum to maximum amount of MAC isoflurane required to maintain SE between 40-60 Total consumption of vecuronium and fentanyl Total intraoperative consumption of atropine and ephedrine Comparison of the amount of isoflurane and vecuronium consumed in both the groups Timepoint: Preoperative At the time of induction Intraoperative Postoperative

—

Secondary

Measure	Time frame
NilTimepoint: Nil	—

Countries

India

Contacts

Public ContactDr Jyotsna Punj

jyotsna_punj@yahoo.com91-11026594606

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026