Evaluation of activity of cytochrome P450 2D6 (CYP 2D6) in normal healthy adult Maharashtrian, Gujarati and Marwari subjects (Western India) by phenotyping and genotyping

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2010/091/000030

Enrollment

600

Registered

2010-01-25

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Dextromethorphan: 60 mg (10 ml) single dose orally Control Intervention1: NIL: NIL

Eligibility

Inclusion criteria

Inclusion criteria: Adult heatlhy male and female, 18 to 45 years with no history of chronic illness and non-smokers and not on any medications metabolised by CYP4502D6 and normal on physical examination who are willing to give informed consent to participate in the study

Exclusion criteria

Exclusion criteria: history of git, renal, liver, cardiovascular, respiratory and endocrine diseases. unwilling to comply protocol requirements. Dextromethorphan use in last 7 days.

Design outcomes

Primary

Measure	Time frame
To classify western indian population into poor or rapid metabolisers by phenotyping and genotyping correlationTimepoint: Single	—

Secondary

Measure	Time frame
NILTimepoint: NIL	—

Countries

India

Contacts

Public ContactDrNithya Gogtay

Seth GS Medical College and KEM Hospital, Mumbai

njgogtay@hotmail.com02224133767

Outcome results