Effects of strength training in patients undergoing dialysis on biochemical parameters, functional capacity and quality of life.

Impact of short term structured Progressive Resistance Training (PRT) in intradialytic patients (DiaPRE study) in the improvement of small solute clearance, functional capacity, Health related quality of life (HQRL), and anthropometric measures ? double blind randomized parallel group active controlled trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2010/091/000014

Enrollment

Registered

2010-01-13

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Progressive resistance training (PRT): Initial - 60% of 5Repetition maximum progressing 10% every two week for 12 weeks, 8 exercises, 3 sets, 10 times each exercise Control Intervention

Eligibility

Inclusion criteria

Inclusion criteria: ? Should have end stage renal disease (diagnosed by the physician and the stage of the disease according to the international association for nephrology) for more than 6 months and dialysis for atleast 3 months (the impact of exercise training can be easily assessed) ? Should have been between the ages of 30 ? 60 years of age/ both genders.

Exclusion criteria

Exclusion criteria: ?Those with acute nephritic syndrome and hematuria. ?Those with profound anemia and continuous blood transfusion ?Undergone a renal transplantation. ?Received cytotoxic drugs ? amilidiriones, azanthioprine/ aspirin (antiplatelets) ? Coagulation disorders ?Recent valvular transplantations and with recent unstable cardiac failures ?Recent urinary tract infections, Renal and bladder carcinomas ?Absolute contraindications for resistance exercise training.

Design outcomes

Primary

Measure	Time frame
1.Fat levels: Jacksons and Siri?s formula the calculation of fat through the skin fold measurements. 2.Heart rate recovery through 3 minute step test (VO2 max): Queens college protocol 3.Hand grip: best of 3 hand grip measurements by the Jammer dynamometer 4.6 minute walk test: as proposed by American Thoracic Society 5.Functional wellbeing (Quality of Life) - SF - 36 Timepoint: all the outcome measures to be measured at the beginning of the study and at the complettion of study (at 0th week and 12th week)	—

Measure

Time frame

1.Fat levels: Jacksons and Siri?s formula the calculation of fat through the skin fold measurements. 2.Heart rate recovery through 3 minute step test (VO2 max): Queens college protocol 3.Hand grip: best of 3 hand grip measurements by the Jammer dynamometer 4.6 minute walk test: as proposed by American Thoracic Society 5.Functional wellbeing (Quality of Life) - SF - 36 Timepoint: all the outcome measures to be measured at the beginning of the study and at the complettion of study (at 0th week and 12th week)

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Secondary

Measure	Time frame
1.BMI: weight in Kgs/ Height in meters2 2.Bimonthly blood profile (RBC/ hemotocrit) 3.Bimonthly blood biochemistry ? C reactive protein, Serum albumin, creatinine index and transthyretin 4.Bimonthly small solute clearance (urea clearance & protein catabolic rate ) 5.Depression: 6.fatigue Timepoint: biochemistry values will be measured bimonthly whereas the rest measures at the commencement and finally at the completion of the study.	—

Measure

Time frame

1.BMI: weight in Kgs/ Height in meters2 2.Bimonthly blood profile (RBC/ hemotocrit) 3.Bimonthly blood biochemistry ? C reactive protein, Serum albumin, creatinine index and transthyretin 4.Bimonthly small solute clearance (urea clearance & protein catabolic rate ) 5.Depression: 6.fatigue Timepoint: biochemistry values will be measured bimonthly whereas the rest measures at the commencement and finally at the completion of the study.

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Countries

India

Contacts

Public ContactManish Goon

Assistant Professor

bbcsarma@gmail.com+91 9933440046

Outcome results