A clinical trial to study the effect of two drugs, granisetron and combination of granisetron-dexamethasone on postoperative nausea and vomiting in children undergoing strabismus surgey

Is addition of dexamethasone increases the efficacy of granisetron for prevention of postoperative nausea and vomiting in pediatric strabismus surgery?

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2009/091/001000

Enrollment

120

Registered

2009-12-11

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- children undergoing strabismus surgery

Interventions

Intervention1: drug - granisetron: 40mcg/kg, once daily Intervention2: granisetron-dexamethasone: granisetron (40mcg/kg)-Dexamethasone (150mcg/kg) once Control Intervention1: granisetron: 40mcg/kg, on

Eligibility

Inclusion criteria

Inclusion criteria: All children aged 1-14 years undergoing elective strabismus surgery

Exclusion criteria

Exclusion criteria: i. Refusal to participate by parents ii. Difficult airway iii. Mental retardation iv. Severe cardiac/ respiratory disease v. taking drugs which have antiemetic action (phenothiazines, corticosteroids, tricyclic antidepressant) vi. previous history of motion sickness

Design outcomes

Primary

Measure	Time frame
incidence and severity of Post operative nausea and vomiting in first 24 hours after surgeryTimepoint: 24 hours after surgery;incidence and severity of Post operative nausea and vomiting in first 24 hours after surgeryTimepoint: 24 hours after surgery	—

Secondary

Measure	Time frame
ready to shift to ward from recovery room, parents satisfactionTimepoint: 24 hours postoperatively;ready to shift to ward from recovery room, parents satisfactionTimepoint: 24 hours postoperatively	—

Countries

India

Contacts

Public ContactDr Renu Sinha

renuagarwal4@rediffmail.com011-26252858

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 2, 2026