Health Condition 1: null- Pateints admitted to the deptt of Gastroenterology AIIMS with acute pancreatitis
Conditions
Interventions
Intervention1: Oral Glutamine: 20gm in two doses of 10 gm each for 7 days
Control Intervention1: oral whey protein: 20 gms in 2 doses of 10 gm each for 7 days
Sponsors
ICMR
Eligibility
Inclusion criteria
Inclusion criteria: All patients admitted to gastroenterology ward of AIIMS with acute pancreatitis defined by compatible abdominal pain associated with raised S amylase >3xULN and suggestive imaging shall be included.Among those with severe acute pancreatitis shall be included in the study
Exclusion criteria
Exclusion criteria: <18 yrs to > 80 yrs Renal failure at onset or within 7 days of study Patients who had already received enteral nutrition prior to inclusion in the study. Absence of - Advanced. Chronic Liver Disease, - Inflammatory Bowel Disease - Celiac disease - Cystic fibrosis - Major surgery - Patient already on NSAIDS - Pregnancy - Lack of informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate change in intestinal permeability (IP) in patients with SAP at onset followed by repeat evaluation of IP after oral Glutamine supplementation compared to those who receive whey protein. Change in endotoxin levels (markers of endotoxemia IgG and IgM) in both groups after supplementation. Timepoint: 7 days after supplementation, Tests will be done pre supplementation and 7 days after supplementation. | — |
Secondary
| Measure | Time frame |
|---|---|
| biochemiA. Clinical Infectious complication Total hospital stay Other infectious complication Duration of ICU stay B. Biochemical parameters CRP Pre-albumin Timepoint: for clinical secondary outcome entire hospital stay will be included for biochemical parameters will be done prior to and 7 days after supplementation | — |
Countries
India
Contacts
Public ContactDr Anoop Saraya
Outcome results
None listed