None listed
Conditions
Interventions
Intervention1: Arm-1: 12.5mg Fe, 938 IU vit A, 0.38mg Vit B1, 5mg Vit B3, 0.38mg Vit B6, 0.008mg Vit B12, 0.008mg Folic acid, 3mg Zn
Intervention2: ARM-2: 6.3mg Fe, 938 IU Vit A, 0.38mg Vit B1, 5mg Vi
Sponsors
St John's Research Institute, St. John's National Academy of Health Sciences, Bangalore, India
Eligibility
Inclusion criteria
Inclusion criteria: - Primary school children registered into the selected school(s) - 6-12y mild-moderately anemic (Hb >90 g/L and <115 g/L for children aged 5-11 y; Hb > 90g/L and <120 g/L in children 12y).
Exclusion criteria
Exclusion criteria: - Taking micronutrient supplements - Have major medical conditions other than mild-moderate anemia - Severely anemic (Hb<90 g/L) - Severely malnourished (weight-for-height z-score <-3) - Girls who have started their menstruation prior to enrolment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary objective is to examine the effect of multiple-micronutrient fortified rice on hemoglobin level and anemia prevalence among mild-moderately anemic school children in Bangalore, India.The primary outcomes will be the change in haemoglobin concentration and prevalence of anemia.Timepoint: 28 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary objective is to determine whether the provision of multiple-micronutrient fortified rice will improve iron and other micronutrient (i.e., vitamin A, vitamin B, and zinc) status and reduce ID and IDA in school children. The impact of fortified rice on the physical growth and incidence of morbidity such as diarrhea will be assessed. In addition, it will be assessed whether the cognitive and physical performance of school children improves after consuming rice fortified with multiple-micronutrient 6 days a week for a period of 7 months.The secondary end point variables will be: 1) Biochemical outcomes (serum concentrations of ferritin, transferrin receptor, zinc protoporphyrin, retinol, zinc, homocysteine) - Serum ferritin (SF), transferrin receptor (TfR), zinc protoporphyrin (ZnPP) - SF or TfR + ZnPP: prevalence of iron deficiency - SF + Hb or TfR + ZPP + Hb: prevalence of iron deficiency anemia - Serum retinol (SR); Vitamin A deficiency - Serum zinc (SZn): zinc deficiency 2) Physical growth (body weight, height) - Body weight - Height 3) Physical performance, Cognitive development and performance - Short term memory - Reasoning ability - Language production - Visuo-spatial ability - Attention / concentration 5) Morbidity (frequency of morbidity with common illnesses) - Frequency of morbidity: e.g., high fever, diarrhea, absenteeism from school due to illness etc Timepoint: 28 weeks | — |
Countries
India
Contacts
Public ContactDr.Prashanth Thankachan
Outcome results
None listed