None listed
Conditions
Interventions
Intervention1: Grafting autologous oral mucosal epithelial cells on human amniotic membrane: autologous
oral mucosal epithelial cells
Control Intervention1: Pre-operative status of same eye: vision
schirmer'
s test
clinical picture taken on slit lamp to evaluate epithelial surface
Sponsors
Dr. Radhika Tandon
Eligibility
Inclusion criteria
Inclusion criteria: Patients with bilateral ocular surface disease with bilateral limbal stem cell deficiency with vision < 6/60 with quiescent disease for >1yr without inflammation or trachomatous scarring who are willing to give informed consent and come for regular post-op follow-up. Patients should not be long term tobacco users.
Exclusion criteria
Exclusion criteria: Simultaneous presence of any other ocular anterior segment disease or any other systemic disease which seriously compromises the general condition / immune response of the individual; pregnant / lactating mothers / patients with vision > 6/60; patients who are unwilling to come for regular post-op follow up or those who refuse to give consent to enroll in the study; patients with known hypersensitivity / allergy to common drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Re-epithelialization with a stable ocular surface.Timepoint: 1 month post-operative | — |
Secondary
| Measure | Time frame |
|---|---|
| Absence of goblet cells on the cornea with presence of goblet cells on the conjunctiva tested by impression cytologyTimepoint: 3 months post-operative | — |
Countries
India
Contacts
Public ContactDr. Radhika Tandon
Dept. of Ophthalmology, Dr. R. P. Centre, AIIMS, New Delhi, India
Outcome results
None listed