A clinical trial to study the efficacy of steroids versus steroids and pentoxifylline in the treatment of patients with severe acute alcoholic hepatitis

A randomized, controlled trial to study the efficacy of steroids versus steroids and pentoxifylline in severe acute alcoholic hepatitis

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2009/091/000876

Enrollment

Registered

2009-11-10

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Prednisolone and Pentoxifylline: Prednisolone 40 mg per day and Pentoxifylline 400 mg thrice a day for 4 weeks Control Intervention1: Prednisolone: 40 mg pre day for 4 weeks

Eligibility

Inclusion criteria

Inclusion criteria: Patients of alcoholic hepatitis with modified Maddrey?s Discriminant factor (DF) &#8805; 32

Exclusion criteria

Exclusion criteria: Improvement in DF with symptomatic treatment for 5-7 days Positive viral serology for HAV, HBV, HCV or HEV Concomitant bacterial or fungal infections Active gastrointestinal haemorrhage Severe cardiovascular or pulmonary diseases Neoplastic and other inflammatory conditions

Design outcomes

Primary

Measure	Time frame
Reduction in MortalityTimepoint: 4 weeks	—

Secondary

Measure	Time frame
Improvement in Hepatic functionsTimepoint: 4 weeks	—

Countries

India

Contacts

Public ContactDr Sandeep Sidhu

Professor

dmcgastro@in.com0161- 2402855

Outcome results