Toxicity with Tomotherapy based Intensity Modified Radiation Therapy in Head and Neck cancers and in vivo prediction of radio-responsiveness of oropharyngeal cancers using Raman Spectroscopy.

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2009/091/000851

Enrollment

Registered

2009-12-08

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Radiotherapy: Nil Control Intervention1: Nil: Nil

Eligibility

Inclusion criteria

Inclusion criteria: ? Biopsy proven Squamous cell carcinoma of the oropharynx, hypopharynx and larynx. ? AJCC stage T1-3 ,N0-2c, M0 patients with pre treatment tumour measurements. ? Surgery of the primary tumor limited to a biopsy. ? KPS>=60 ? Age>=18 and <=70 years ? No prior history of therapeutic irradiation. ? Patient willing and reliable for follow up. ? Patients nutritional and physical condition compatible with planned therapy. ? Signed study specific consent form.

Exclusion criteria

Exclusion criteria: ? T1N0 M0 of vocal chords ? T4 tumor , N3 Nodal stages ? Evidence of distance metastasis. ? Previous therapeutic irradiation for head and neck cancer. ? Active untreated infection which preclude the use of systemic chemotherapy or would interfere with completion of treatment ? Any histopathology other than Squamous carcinoma ? Primary nasopharyngeal cancers ? Pregnant or lactating woman.

Design outcomes

Primary

Measure	Time frame
To determine and quantify salivary toxicity with Tomotherapy based IMRT treatment of HNSCCTimepoint: NA	—

Secondary

Measure	Time frame
To determine the feasibility of using Raman Spectroscopy in ?vivo in predicting radiation response in patients with oropharyngeal cancers.Timepoint: Nil	—

Countries

India

Contacts

Public ContactDr Vedang Murthy

Nil

vmurthy@actrec.gov.in022-27405000

Outcome results