A clinical trial to compare the usefulness of priming [giving a small dose of the drug prior to the full dose] with propofol during induction of anesthesia with the standard practice of single dose administration and also to compare their safety

Efficacy and safety of priming with propofol Vs standard practice of single dose administration during induction of anesthesia

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2009/091/000768

Enrollment

Registered

2010-03-17

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Propofol induction with priming: 1-2mg/kg total dose,20% of this given as priming dose, speed of injection

30 mg over 10 seconds Control Intervention1: Propofol induction without priming: 1-2 mg/kg total dose, speed of injection 30mg/sec

Eligibility

Inclusion criteria

Inclusion criteria: American Society of Anesthesiology Physical status class I [healthy patient] or class II [mild systemic disease] patients in the age group 18-55 yrs of age posted for elective surgery.

Exclusion criteria

Exclusion criteria: Pregnant and lactating women Patients allergic to study medications Patients with uncorrected hypotension Patients with valvular heart disease.

Design outcomes

Primary

Measure	Time frame
Reduction in dose requirement as evidenced by successful anesthesia with less dose.Timepoint: Successful anesthesia is defined by the time point when there is loss of verbal response of the patient.	—

Secondary

Measure	Time frame
Hemodynamic stability as evidenced by proportion of subjects with blood pressure and heart rate fluctuation within 15% of mean.Timepoint: BP and heart rate,30 mins prior to surgery,just before induction of anesthesia,1 min after induction,immediately after intubation and 5 mins after induction	—

Countries

India

Contacts

Public ContactDr Unnikrishnan P

drunnikrishnanp@gmail.com04742761649

Outcome results