Health Condition 1: null- Muscle Invasive Bladder Cancer
Conditions
Interventions
Intervention1: Tomotherapy based IMRT: Tomotherapy based IMRT, to a dose of 64Gy in 32# to the whole bladder. Simultaneous Integrated Boost to the tumour bed and concomittant chemotherapy with weekly
Sponsors
Tata Memorial Hospital
Eligibility
Inclusion criteria
Inclusion criteria: ? Age > 18 years old: Male and Female ? Histologically proven invasive bladder transitional cell carcinoma ? AJCC clinical stages T2-T4a, Nx or N0, M0 ? Thorough evaluation by a urologist and have undergone as thorough a TURBT as is judged safely possible ? KPS>= 70 ? Able to tolerate systemic chemotherapy combined with pelvic radiation therapy by the joint agreement of the participating Urologist, Radiation Oncologist and Medical Oncologist. ? Hemoglobin >= 10 mg/dl, WBC >= 3000/ml, Absolute neutrophil count of >= 1800/ml, Platelet count of >= 100,000/mm3, Serum creatinine < 1.5 mg%, Serum bilirubin of 2.0mg% ? Ability to take daily treatment ? Only patients with a solitary, well defined tumour will be considered for the boost protocol ? Protocol treatment to begin a maximum of 30 days following TURBT
Exclusion criteria
Exclusion criteria: Prior pelvic radiation therapy. ? Incontinence, need for cathererisation ? Hydronephrosis attributable to the tumour ? Pregnancy ? Previous malignancy that is likely to interfere with protocol treatment ? Inflammatory bowel disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome of the study is to assess the Dosimetric evaluation of Intensity Modulated Radiotherapy treatment for whole and partial Bladder radiotherapy. , novel Adaptive Radiotherapy Technique and set up errors and Internal organ motion with IGRT.Timepoint: NA | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary outcome of the study is to assess the acute and late toxicity, local control and bladder preservation rate.Timepoint: NA | — |
Countries
India
Contacts
Public ContactDr Vedang Murthy
ACTREC, Tata Memorial Centre
Outcome results
None listed