Safety and efficacy of low dose MgSo4 regimen for eclampsia treatment

Safety and efficacy of low dose MgSo4 regimen for treatment of eclampsia

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2009/091/000339

Enrollment

Registered

2009-08-05

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Mg so4 intravenous Vs low dose intramuscular: Group I : This group will include 25 patients with antepartum eclampsia. They will receive 4 gm of magnesium sulphate intravenously as a

Eligibility

Inclusion criteria

Inclusion criteria: Patients with antepartum eclampsia

Exclusion criteria

Exclusion criteria: ? Comatosed patient ? Pulmonary oedema ? Oliguria /renal failure ? Patient who have received MgSO4, phenytoin, diazepam before coming to hospital. ? Intra-cranial bleeding

Design outcomes

Primary

Measure	Time frame
Outcome measures: Maternal ? Recurrence of fits, signs of magnesium toxicity(like loss of knee jerk,respiratory depression) , oliguria any other maternal complications like coagulation failure ,renal failure , pulmpnary oedema will be recorded. Other parameter like need for extra dose for Mgso4, need for diazepam or need for switch over to phenytoin will also be recorded. Details of labour and delivery will be recorded. Neonatal: Neonatal outcome like still born ,live born, Aphgar score, hypotonia, respiratory depression , requirement for calcium gluconate ,need for NICU care, jaundice and any other morbidity and mortality will be recorded. Timepoint: Till the time of treatment and post partum period	—

Measure

Time frame

Outcome measures: Maternal ? Recurrence of fits, signs of magnesium toxicity(like loss of knee jerk,respiratory depression) , oliguria any other maternal complications like coagulation failure ,renal failure , pulmpnary oedema will be recorded. Other parameter like need for extra dose for Mgso4, need for diazepam or need for switch over to phenytoin will also be recorded. Details of labour and delivery will be recorded. Neonatal: Neonatal outcome like still born ,live born, Aphgar score, hypotonia, respiratory depression , requirement for calcium gluconate ,need for NICU care, jaundice and any other morbidity and mortality will be recorded. Timepoint: Till the time of treatment and post partum period

—

Secondary

Measure	Time frame
nilTimepoint: nil	—

Countries

India

Contacts

Public Contactpradipkumar saha

Assistant professor,dept of Obstetrics and gynaecology,gmch, chandigarh

pradiplekha@yahoo.co.in1722645262

Outcome results