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A clinical trial to compare the effectiveness of a drug, Ephedrine with crystalloid infusion to prevent spinal anaesthesia induced hypotension.

Efficacy of Ephedrine infusion against crystalloid preloading to prevent hypotension during spinal anaesthesia for elective lower abdominal surgeries in a tertiary care centre- An open randomized controlled trial.

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2009/091/000150
Enrollment
Unknown
Registered
2009-05-19
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Ephedrine: 5 mg per minute for 2 minutes and then 1 mg per minute for 18 minutes Control Intervention1: Normal Saline: 15 ml per kg

Sponsors

nil
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1) Patients belonging to age groups 20 to 60 2) ASA grades 1 and 2 patients of both sexes 3) Type of surgery - Elective lower abdominal surgeries

Exclusion criteria

Exclusion criteria: 1) Patients below 20 years and above 60 years 2)ASA grades more than 2 3) Patients with spinal deformities, previous spine surgeries, coagulation abnormalities, serious pulmonary and cardiovascular diseases 4)Patients with intra abdominal mass/ pregnancy 5)Patients with documented drug allergy to Bupivacaine or Ephedrine 6)Patients in whom anticipated operative blood loss is greater than 10% of blood volume 7)Patients not willing to give consent

Design outcomes

Secondary

MeasureTime frame
Side effects of Ephedrine if anyTimepoint: 1 min, 2 min, 4 min, 6 min, 8 min, 10 min, 20 min, 30 min, 40 min, 50 min, 60 min, 70 min, 80 min, 90 min, 100 min, 110 min, 120 minutes.—

Primary

MeasureTime frame
HypotensionTimepoint: 1 min,2 min, 4 min, 6 min, 8 min, 10 min, 20 min,30 min, 40 min,50 min, 60 min,70 min, 80 min, 90 min, 100 min, 110 min, 120 min.—

Countries

India

Contacts

Public ContactDr Divya Madhu
mail2divyamadhu@yahoo.co.in04712450446

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026