A clinical trial to study the effects of two modalities of intravenous furosemide injection, continuous infusion and intermittent injections, in the management of edema (swelling) in children with nephrotic syndrome

COMPARATIVE EFFICACY OF FUROSEMIDE BY CONTINUOUS INTRAVENOUS INFUSION VERSUS INTERMITTENT BOLUS ADMINISTRATION IN NEPHROTIC CHILDREN WITH MODERATE TO SEVERE EDEMA

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2009/091/000059

Enrollment

Registered

2009-03-12

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: continuous intravenous furosemide infusion: Loading dose 1.6mg/kg, followed by infusion @ 0.1mg/kg/hr for 24 hours Control Intervention1: Intermittent intravenous bolus furosemide injec

Eligibility

Inclusion criteria

Inclusion criteria: Children diagnosed as nephrotic syndrome in the age group of 1 to 14 years, admitted for edema control were enrolled in the study if they had previously failed to respond to oral furosemide treatment in a dose of 2mg/kg/day

Exclusion criteria

Exclusion criteria: Hemodynamic instability Serious infections (like meningitis, peritonitis etc.) Congestive cardiac failure Diarrhea, vomiting, hypovolemia Dyselectrolytemia Schwartz GFR (<40ml/min/1.73m2 calculated by formula)

Design outcomes

Primary

Measure	Time frame
Change in total urinary outputTimepoint: During the intervention	—

Secondary

Measure	Time frame
Percentage weight loss ,Change in Osmolal clearance, Change in free water clearance,Total urinary sodium and potassium,Urinary sodium and potassium ,Fractional excretion of sodium ,Serum sodium and potassium ,Complications of treatment [Delete] Timepoint: During the intervention	—

Countries

India

Contacts

Public ContactDr. Kamran Afzal

nil

drkafzal@hotmail.com05712721182

Outcome results