Health Condition 1: null- Post renal transplant recipients after at least 3 weeks of renal transplantation
Conditions
Interventions
Intervention1: blood sampling: No pharmacological intervention in the ongoing treatment as per local practice, only 2 mL blood samples for 3 times taken for plasma level estimation
Control Interventio
Sponsors
DEPARTMENT OF PHARMACOLOGY AIIMS NEW DELHI
Eligibility
Inclusion criteria
Inclusion criteria: Patients coming for follow up at Nephrology Outpatient Department at AIIMS, New Delhi, who were having renal transplantation for at least 3 weeks before, age between 20-60 years, belonging to either sex, receiving MMF or EC-MPS for a minimum period of 7 days with tacrolimus and steroid in the treatment regimen were candidates for inclusion in the study.
Exclusion criteria
Exclusion criteria: Patients not agreed for written informed consent, using any other immunosuppressant, insufficient address for follow-up, or unwillingness to return for follow-up were not admitted to the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcomeTimepoint: The primary endpoint was to correlate mycophenolic acid area under the concentration-time curve with acute graft dysfunction episodes and adverse drug events. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomeTimepoint: Additional analyses were done on the correlation of mycophenolic acid area under the concentration-time curve with patient reported outcomes, concomitant tacrolimus dosing, age, sex, MPA formulations. | — |
Countries
India
Contacts
Public ContactProfessor Y K Gupta
Junior resident
Outcome results
None listed