None listed
Conditions
Interventions
Intervention1: Prednisolone at 0.75 mg/kg every day for 7 days during an infection.: Pednisolone at 0.75 mg/kg every day for 7 days during infection then continued on alternate day at 0.5-0.75 mg/kg
C
Sponsors
ICMR
Eligibility
Inclusion criteria
Inclusion criteria: Patients with idiopathic, steroid responsive nephrotic syndrome, 1 to 16 years' old, having frequent relapses or steroid dependence shall be studied. Only patients with a minimum follow up of 9 months at this center will be included. Standard definitions will be used for defining the course of nephrotic syndrome
Exclusion criteria
Exclusion criteria: 1. Patients with impaired renal functions (serum creatinine > 1.2 mg/dl or urea > 45 mg/dl, confirmed once over a period of 2 weeks). 2. Patients with initial or late steroid resistance. 3. Patients who have received immunosuppressive medications, other than oral prednisolone, in the preceding 6 months. 4. Patients who require prednisolone at dose exceeding 1 mg/kg on alternate days for maintaining remission. 5. Patients with features of steroid toxicity (obesity, cataract, hypertension) (Table 1). 6. Patients staying more than 100 km from the Institute or those who not willing to come for clinic visits every two months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Relapse rates (episodes/patient per year) will be compared in both groups, in the six months prior and during one-year follow up.Timepoint: 12 months | — |
Secondary
| Measure | Time frame |
|---|---|
| cumulative dose of prednisolone administered (mg/kg per day) will be compared 6-months prior and during the period of the study in the two groups. The frequencies of intercurrent infections shall be determined.Timepoint: 12 months | — |
Countries
India
Contacts
Public ContactDr. Arvind Bagga
Outcome results
None listed