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A clinical study to assess the effects of two drugs, atorvastatin and pioglitazone in patients of high blood pressure or angina, but without diabetes

Effects of Atorvastatin and Pioglitazone on Endothelial Dysfunction in non-diabetic patients with hypertension or stable angina

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2008/091/000169
Enrollment
Unknown
Registered
2008-11-03
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: atorvastatin: 10mg OD for 12 weeks Intervention2: Pioglitazone: 30 mg OD for 12 weeks Intervention3: Pioglitazone: 15 mg OD for 12 weeks Control Intervention1: NOT APPLICABLE: NOT APPLI

Sponsors

NIL
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients with stable angina between 35-65 years belonging to both sexes. Patients with hypertension between 35-65 years belonging to both sexes

Exclusion criteria

Exclusion criteria: Diabetes mellitus Hepatic/renal dysfunction Tobacco consumption in any form within previous 6 months Pregnant or lactating women CHF [NYHA class II TO IV] Recent myocardial infarction History of unstable angina. History of allergy to statins or pioglitazone Severe or uncontrolled hypertension(>160/110 mmHg)

Design outcomes

Primary

MeasureTime frame
Clinical and Biochemical markers of endothelial dysfunctionTimepoint: 0 and 12 weeks(Before and after intervention)—

Secondary

MeasureTime frame
Comparison of side effects between the 3 study armsTimepoint: 2 weekly telephonic history during the 12 week treatment period.—

Countries

India

Contacts

Public ContactDr. Sandeep Seth

Junior Rsident, Department of Pharmacology

dr.pattan@gmail.com011 26593540

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026