None listed
Conditions
Interventions
Intervention1: Two tablets containing 10 mg zinc sulfate each or placebo will be given to the study subjects at admission. From day 2, the children would receive 10 mg of their assigned treatment by m
Sponsors
B P Koirala Institute of Health Sciences
Eligibility
Inclusion criteria
Inclusion criteria: Children between 2 months to 5 years of age with severe pneumonia (as defined by WHO/IMCI) admitted to Pediatric Wards of B. P. Koirala Institute Health Sciences, whose parents are willing to provide written informed consent will be eligible for inclusion in the study
Exclusion criteria
Exclusion criteria: • Children suffering from severe malnutrition (as defined by WHO) or severe anemia (Hb < 8 g/dL) • Pneumonia due to measles, aspiration of foreign body • Presence of hepatic or renal disease • Congenital abnormalities ( cardiac, renal disease, or genetic) • Complicated pneumonia (lung abscess, pleural effusion, pneumatocele, atelectasis • Previous IV antibiotic for more than 24 hours
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to resolution of severe pneumoniaTimepoint: The duration from the enrolment till the symptoms/signs of severe pneumonia are no longer present and continue to be absent for next 24 hours.;Duration of hospitalizationTimepoint: Time (In hours) from the day of enrolment until the day of discharge from hospital | — |
Secondary
| Measure | Time frame |
|---|---|
| Failure rateTimepoint: Non-response after 48 hours of antibiotic therapy;Fever clearance timeTimepoint: Time from enrolment till disappearance of fever;Time to complete recovery from pneumoniaTimepoint: Enrolment till Normalization of Respiratory Rate (RR);Time to start oral feedsTimepoint: Time from enrolment till oral feeds started and continued for 24 hours. | — |
Countries
Nepal
Contacts
Public ContactDr. Gauri Shankar Shah
Outcome results
None listed