To determine the effect of instillation of lignocaine down the endotracheal tube in attenuating airway and circulatory response to extubation

Instillation of lignocaine down the endotracheal tube to attenuate extubation response - none

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2008/091/000027

Enrollment

114

Registered

2008-05-07

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: lignocaine: dose 1mg/kg intravenously or through the endotracheal tube at the end of surgery. Control Intervention1: normal saline: Control Intervention2: normal saline 0.9%: at dose o

Eligibility

Inclusion criteria

Inclusion criteria: Patients undergoing craniotomies with GCS 15/15. Age 18-65 years inclusive. ASA grade 1 & 2.(American Society of Anaesthesiologists grade)

Exclusion criteria

Exclusion criteria: Patients with 1.Sore throat/Active U.R.I 2.Requirement for postop ventilation. 3.History of laryngeal/ tracheal pathology/ surgery. 4.History of asthma/ COPD.

Design outcomes

Primary

Measure	Time frame
cough at extubationTimepoint:	—

Secondary

Measure	Time frame
hemodynamics at extubation, time taken for extubation, post op sore throat.Timepoint: ;plasma levels of lignocaineTimepoint: at extubation and at 10 minutes after extubation	—

Countries

India

Contacts

Public ContactSmitha Elizabeth George, Georgene Singh

gracekorula@hotmail.com0416-2282105

Outcome results