and/or prediabetes)., hyperlipidemia, Overweight or class I obesity (BMI 25.0–34.9 kg/m²), with or without cardiometabolic risk factors (hypertension
Conditions
Brief summary
Percent change in body weight from baseline to 6 months, with absolute change in body weight (kg) as a supportive measure.
Detailed description
Proportion of participants achieving ≥5% reduction in body weight from baseline., Participants will be classified into ordered categories based on obesity status (BMI ≥30 kg/m² vs <30 kg/m²) and number of cardiometabolic risk conditions (central adiposity, hypertension, hyperlipidemia, prediabetes/type 2 diabetes), forming a composite ordinal outcome analyzed using proportional odds models.
Interventions
DRUGBUPROPION
Sponsors
Uppsala University
Eligibility
Sex/Gender
All
Age
18 Years to 64 Years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percent change in body weight from baseline to 6 months, with absolute change in body weight (kg) as a supportive measure. | — |
Secondary
| Measure | Time frame |
|---|---|
| Proportion of participants achieving ≥5% reduction in body weight from baseline., Participants will be classified into ordered categories based on obesity status (BMI ≥30 kg/m² vs <30 kg/m²) and number of cardiometabolic risk conditions (central adiposity, hypertension, hyperlipidemia, prediabetes/type 2 diabetes), forming a composite ordinal outcome analyzed using proportional odds models. | — |
Outcome results
None listed