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Effect of GABAergic treatments on cortical plasticity and motor learning capacity in the subacute phase after stroke: a single-case experimental study (GABAPLAST)

Status
Not yet recruiting
Phases
Phase 3
Study type
Interventional
Source
EU CTIS
Registry ID
CTIS2026-526884-39-00
Enrollment
12
Registered
2026-09-01
Start date
Unknown
Completion date
Unknown
Last updated
2026-09-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke

Brief summary

Variation (Δ) in the amplitude of the motor evoked potential (MEP) induced by a Paired Associative Stimulation (PAS) protocol, expressed as the percentage change between pre-PAS and post-PAS measurements, assessed at each session

Detailed description

Cortical excitability (TMS): resting motor threshold, MEP amplitude and latency, assessed at each session., Motor learning performance: learning effect, rebound, and retention on SRTT and Target Jump tasks, assessed at each session., Safety: spontaneous report on adverse events, assessed at each session, Severity of the symptom that led to treatment prescription reported by the patient using the Patient Global Impression of Severity (PGI-S)

Interventions

DRUGLIORÉSAL 10 mg
DRUGcomprimé sécable
DRUGNEURONTIN 100 mg
DRUGgélule
DRUGNEURONTIN 300 mg
DRUGNEURONTIN 400 mg
DRUGcomprimé

Sponsors

Centre Hospitalier Universitaire De Toulouse
Lead SponsorOTHER

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Design outcomes

Primary

MeasureTime frame
Variation (Δ) in the amplitude of the motor evoked potential (MEP) induced by a Paired Associative Stimulation (PAS) protocol, expressed as the percentage change between pre-PAS and post-PAS measurements, assessed at each session

Secondary

MeasureTime frame
Cortical excitability (TMS): resting motor threshold, MEP amplitude and latency, assessed at each session., Motor learning performance: learning effect, rebound, and retention on SRTT and Target Jump tasks, assessed at each session., Safety: spontaneous report on adverse events, assessed at each session, Severity of the symptom that led to treatment prescription reported by the patient using the Patient Global Impression of Severity (PGI-S)

Outcome results

None listed

Source: EU CTIS · Data processed: Sep 2, 2026