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A Prospective Diagnostic Trial of Al[¹⁸F]F-NOTA-folate PET in Patients with Suspected Cardiac Sarcoidosis or Infective Endocarditis and Healthy Volunteers (FOL-CARD)

Status
Not yet recruiting
Phases
Phase 1Phase 2
Study type
Interventional
Source
EU CTIS
Registry ID
CTIS2026-526655-59-00
Enrollment
143
Registered
2026-08-24
Start date
Unknown
Completion date
Unknown
Last updated
2026-08-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac Sarcoidosis, Infective endocarditis

Brief summary

Quantitative uptake of Al[18F]F-NOTA-folate measured by PET in the left ventricular myocardium in suspected cardiac sarcoidosis and in valvular regions in suspected infective endocarditis

Detailed description

Diagnostic performance of Al[18F]F-NOTA-folate PET for cardiac sarcoidosis and native or prosthetic valve infective endocarditis, Change in myocardial Al[18F]F-NOTA-folate uptake following immunosuppressive therapy in cardiac sarcoidosis, Biodistribution, stability, and radiation dosimetry of Al[18F]F-NOTA-folate in healthy volunteers, Incidence and severity of adverse events related to Al[18F]F-NOTA-folate

Interventions

DRUGAl[ 18 F]F-NOTA-folate

Sponsors

Turku University Hospital
Lead SponsorOTHER

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Design outcomes

Primary

MeasureTime frame
Quantitative uptake of Al[18F]F-NOTA-folate measured by PET in the left ventricular myocardium in suspected cardiac sarcoidosis and in valvular regions in suspected infective endocarditis

Secondary

MeasureTime frame
Diagnostic performance of Al[18F]F-NOTA-folate PET for cardiac sarcoidosis and native or prosthetic valve infective endocarditis, Change in myocardial Al[18F]F-NOTA-folate uptake following immunosuppressive therapy in cardiac sarcoidosis, Biodistribution, stability, and radiation dosimetry of Al[18F]F-NOTA-folate in healthy volunteers, Incidence and severity of adverse events related to Al[18F]F-NOTA-folate

Outcome results

None listed

Source: EU CTIS · Data processed: Aug 25, 2026