Reactive aggression
Conditions
Brief summary
Within-subject assessment of aggressivity during various provocative virtual reality scenarios, comparing propranolol doses to placebo. Aggressivity will be measured using: Researcher-observed: Social Dysfunction and Aggression Scale (SDAS-9) and Self-reported state anger: Spielberger Anger Expression Scale (AEX)
Detailed description
Within-subject comparison of mood states using the Profile of Moods State (POMS-SF) questionnaire., Within-subject correlation analysis between primary objective endpoints and biomarkers attributed to propranolol (blood pressure, heart rate)., Within-subject comparison of the aggression Neuropsychological Assessment battery (AgNA), which is composed of various questionnaires, behavioral tasks, pupillometry and electrophysiology (EEG)
Interventions
Sponsors
Radboud universitair medisch centrum Stichting
Eligibility
Sex/Gender
Male
Age
18 Years to No maximum
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Within-subject assessment of aggressivity during various provocative virtual reality scenarios, comparing propranolol doses to placebo. Aggressivity will be measured using: Researcher-observed: Social Dysfunction and Aggression Scale (SDAS-9) and Self-reported state anger: Spielberger Anger Expression Scale (AEX) | — |
Secondary
| Measure | Time frame |
|---|---|
| Within-subject comparison of mood states using the Profile of Moods State (POMS-SF) questionnaire., Within-subject correlation analysis between primary objective endpoints and biomarkers attributed to propranolol (blood pressure, heart rate)., Within-subject comparison of the aggression Neuropsychological Assessment battery (AgNA), which is composed of various questionnaires, behavioral tasks, pupillometry and electrophysiology (EEG) | — |
Outcome results
None listed