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Evaluation of the efficacy, safety, and tolerability of lutetium-177-labeled PSMA ligand in patients with progression of adenoid cystic carcinoma originating from the salivary glands - an open, non-commercial clinical trial

Status
Not yet recruiting
Phases
Phase 2
Study type
Interventional
Source
EU CTIS
Registry ID
CTIS2026-525776-26-00
Enrollment
31
Registered
2026-08-12
Start date
Unknown
Completion date
Unknown
Last updated
2026-08-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

adenoid cystic carcinoma of the salivary glands

Brief summary

Objective response rate

Detailed description

Progression-free survival, Overall survival, Duration of response, Disease specific survival, Quality of life assessment (according to the EORTC QLQ-C30 and EORTC QLQ-H&N43 questionnaires) and the numeric rating scale (NRS), The number and percentage of patients who experienced adverse events of various severity grades according to CTCAE, laboratory test results and vital signs, Quantitative assessment of ¹⁷⁷Lu-PSMA radiotracer uptake on post-therapy scintigraphy after the first and third treatment cycles

Interventions

DRUGPluvicto 1 000 MBq/mL solution for injection/infusion

Sponsors

Narodowy Instytut Onkologii Im. Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy
Lead SponsorOTHER

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Design outcomes

Primary

MeasureTime frame
Objective response rate

Secondary

MeasureTime frame
Progression-free survival, Overall survival, Duration of response, Disease specific survival, Quality of life assessment (according to the EORTC QLQ-C30 and EORTC QLQ-H&N43 questionnaires) and the numeric rating scale (NRS), The number and percentage of patients who experienced adverse events of various severity grades according to CTCAE, laboratory test results and vital signs, Quantitative assessment of ¹⁷⁷Lu-PSMA radiotracer uptake on post-therapy scintigraphy after the first and third treatment cycles

Outcome results

None listed

Source: EU CTIS · Data processed: Aug 13, 2026