Vascular Calcification
Conditions
Brief summary
Difference in pre to post-dialysis change in T₅₀ between the non-dosed session and the STS-dosed session in the same participant., Change in pre-dialysis T₅₀ from the non-dosed control session to each of the three STS-dosed sessions
Detailed description
Within subject differences in CPP amounts between non-dosed and STS-dosed sessions and the STS-dosed sessions, and in pre- to post-dialysis changes within each session., Correlations between changes in T₅₀ and CPP measures across session and timepoints., Within-subject changes in CRP, IL-6, TNF-α and NO/ROS related markers between sessions., Changes in P1NP, CTX, osteocalcin, ALP, bone-specific ALP, phosphate, calcium, PTH, and FGF23 between sessions and timepoints.
Interventions
Sponsors
Radboud universitair medisch centrum Stichting
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference in pre to post-dialysis change in T₅₀ between the non-dosed session and the STS-dosed session in the same participant., Change in pre-dialysis T₅₀ from the non-dosed control session to each of the three STS-dosed sessions | — |
Secondary
| Measure | Time frame |
|---|---|
| Within subject differences in CPP amounts between non-dosed and STS-dosed sessions and the STS-dosed sessions, and in pre- to post-dialysis changes within each session., Correlations between changes in T₅₀ and CPP measures across session and timepoints., Within-subject changes in CRP, IL-6, TNF-α and NO/ROS related markers between sessions., Changes in P1NP, CTX, osteocalcin, ALP, bone-specific ALP, phosphate, calcium, PTH, and FGF23 between sessions and timepoints. | — |
Outcome results
None listed