A prospective, randomized, double-blind, placebo-controlled, multicentre, dose-finding clinical trial with polymerised mannan-conjugated allergoid Dactylis glomerata/Phleum pratense administered subcutaneously to patients with grass pollen-induced allergic rhinitis or rhinoconjunctivitis.

Status

Not yet recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

EU CTIS

Registry ID

CTIS2025-524580-21-00

Enrollment

450

Registered

2026-05-29

Start date

Unknown

Completion date

Unknown

Last updated

2026-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Grass pollen induced allergic rhinitis or rhinoconjunctivitis

Brief summary

Mean daily Combined Symptom and Medication Score (CSMS, as defined in the EAACI position paper by Pfaar et al., 2014) over the peak grass pollen season 2027.

Interventions

DRUGMometason ratiopharm 50 Mikrogramm/Sprühstoß Nasenspray

DRUGSuspension

DRUGPlacebo is identical in appearance an condition to the investigational medicinal product.

DRUGBudes 64 Mikrogramm/Sprühstoß Nasenspray

DRUGAllegra Allergietabletten 20 mg Tabletten

DRUGNASACORT 55 Mikrogramm/Dosis Nasenspray

DRUGHAL Allergy Prick Test Wiesenlieschgras

DRUGEMADINE 0.5 mg/ml

DRUGeye drops

DRUGsolution

DRUGEbastin Aristo 10 mg Filmtabletten

DRUGCetirizin-ratiopharm® bei Allergien Filmtabletten

DRUGDesloratadin Glenmark 5 mg Tabletten

DRUGFexofenadin Winthrop 180 mg Filmtabletten

DRUGAVAMYS 27.5 micrograms/spray

DRUGnasal spray suspension

DRUGBilaxten 6 mg/ml Augentropfen

DRUGLösung

DRUGHAL Allergy Prick Test Katzenepithelien

DRUGOlopatadin Micro Labs 1 mg/ml Augentropfen

DRUGMannan-conjugated allergoid (polymerized) Phleum pratense and Dactylis glomerata parenteral vaccine

DRUGALK Prick Positiv Kontrolle - Lösung für Haut-Pricktest

DRUGRupatadin AL 10 mg Tabletten

DRUGHAL Allergy Prick Test Hundeepithelien

DRUGHAL Allergy Pricktest 10 mg/ml Pricktestlösung zur Positivkontrolle

DRUGHAL Allergy Prick Test Alternaria alternata

DRUGAzelastin COMOD 0

DRUG5 mg/ml Augentropfen

DRUGHAL Allergy Prick Test Gräserpollen-Mischung

DRUGLevocetirizin-ratiopharm 5 mg Filmtabletten

DRUGHAL Allergy Prick Test Hausstaubmilbe Dermatophagoides Pteronyssinus

DRUGLivocab® direkt Augentropfen 0

DRUG05 % Augentropfen

DRUGLoratadin-ratiopharm® 10 mg Tabletten

DRUGALK Prick Negativ Kontrolle - Lösung für Haut-Pricktest

DRUGHAL Allergy Pricktest Negativkontrolle

DRUGPricktestlösung

DRUGAlvesco 160 Mikrogramm Druckgasinhalation

DRUGFlutica-Teva® 50 Mikrogramm Nasenspray

Eligibility

Sex/Gender

All

Age

18 Years to 64 Years

Design outcomes

Primary

Measure	Time frame
Mean daily Combined Symptom and Medication Score (CSMS, as defined in the EAACI position paper by Pfaar et al., 2014) over the peak grass pollen season 2027.	—

Outcome results

None listed

Source: EU CTIS · Data processed: May 30, 2026