Systemic Sclerosis
Conditions
Brief summary
How much the amount of air a person can blow out of their lungs (called Forced Vital Capacity, or FVC) changes. This is measured in milliliters (mL).
Detailed description
How much the skin thickness (measured by the Modified Rodnan Skin Score, or mRSS) changes., Changes in lung function (FVC in mL) or in skin thickness (mRSS)., Changes in the percentage of predicted FVC (ppFVC), which compares a person’s lung function to what is expected for someone their age and size., Changes in how well the lungs transfer oxygen (called DLCO)., How long it takes for the disease to get worse, starting from when a person joins the study.
Interventions
DRUGNINTEDANIB
DRUGFLUDARABINE PHOSPHATE
DRUGTOCILIZUMAB
DRUGCYCLOPHOSPHAMIDE
DRUGRITUXIMAB
Sponsors
Celgene Corp.
Eligibility
Sex/Gender
All
Age
0 Years to No maximum
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| How much the amount of air a person can blow out of their lungs (called Forced Vital Capacity, or FVC) changes. This is measured in milliliters (mL). | — |
Secondary
| Measure | Time frame |
|---|---|
| How much the skin thickness (measured by the Modified Rodnan Skin Score, or mRSS) changes., Changes in lung function (FVC in mL) or in skin thickness (mRSS)., Changes in the percentage of predicted FVC (ppFVC), which compares a person’s lung function to what is expected for someone their age and size., Changes in how well the lungs transfer oxygen (called DLCO)., How long it takes for the disease to get worse, starting from when a person joins the study. | — |
Outcome results
None listed