A PET-MRI study of serotoninergic brainstem pathway in patients with Dravet Syndrome - DRAPETONINE

Conditions

neurology

Brief summary

Comparison of the brainstem BPND of [18F]-MPPF across patients groups (DS and focal epilepsy)

Detailed description

Comparison of the brainstem BPND of [18F]-MPPF of each patients group (DS and focal epilepsy) with the one of healthy subjects, Comparison of the cortical BPND of [18F]-MPPF across patients groups (DS and focal epilepsy) and with the one of healthy subjects, aluating the relation between [18F]-MPPF PET brainstem regional distribution of 5HT1A receptors and inter-ictal respiratory function in patients with DS, Comparing brainstem regional volumes on MRI of patients with DS with the one of patients with drug-resistant focal epilepsy, Comparing brainstem regional volumes on MRI of each patients group (DS and focal epilepsy) with the one of healthy subjects, Evaluating the relation between the brainstem regional volumes on MRI and inter-ictal respiratory function in patients with DS

Related papers

No related papers found yet.

Interventions

DRUG[18F]-MPPF

Eligibility

Sex/Gender

All

Age

18 Years to 64 Years

Design outcomes

Primary

Measure	Time frame
Comparison of the brainstem BPND of [18F]-MPPF across patients groups (DS and focal epilepsy)	—

Secondary

Measure	Time frame
Comparison of the brainstem BPND of [18F]-MPPF of each patients group (DS and focal epilepsy) with the one of healthy subjects, Comparison of the cortical BPND of [18F]-MPPF across patients groups (DS and focal epilepsy) and with the one of healthy subjects, aluating the relation between [18F]-MPPF PET brainstem regional distribution of 5HT1A receptors and inter-ictal respiratory function in patients with DS, Comparing brainstem regional volumes on MRI of patients with DS with the one of patients with drug-resistant focal epilepsy, Comparing brainstem regional volumes on MRI of each patients group (DS and focal epilepsy) with the one of healthy subjects, Evaluating the relation between the brainstem regional volumes on MRI and inter-ictal respiratory function in patients with DS	—

Measure

Time frame

Comparison of the brainstem BPND of [18F]-MPPF of each patients group (DS and focal epilepsy) with the one of healthy subjects, Comparison of the cortical BPND of [18F]-MPPF across patients groups (DS and focal epilepsy) and with the one of healthy subjects, aluating the relation between [18F]-MPPF PET brainstem regional distribution of 5HT1A receptors and inter-ictal respiratory function in patients with DS, Comparing brainstem regional volumes on MRI of patients with DS with the one of patients with drug-resistant focal epilepsy, Comparing brainstem regional volumes on MRI of each patients group (DS and focal epilepsy) with the one of healthy subjects, Evaluating the relation between the brainstem regional volumes on MRI and inter-ictal respiratory function in patients with DS

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Outcome results

None listed