Acute kidney injury, Critical illness, Metabolic acidosis
Conditions
Brief summary
Major adverse kidney events (MAKE90) Binary endpoint consisting of mortality or any KRT within 90 days after randomization or persistent renal dysfunction (creatinine value at day 90 ≥200% of baseline value) at day 90
Detailed description
90-day all-cause mortality (%), Elevation of the creatinine level to ≥200% of baseline value at day 90 (one measurement between day 80 and 120 after randomization), Receipt of any form of KRT within the 90-day time period after randomization, Kidney Replacement Therapy (KRT)-dependence at day 90 after randomization, KRT-free days, defined as difference between number of days alive and number of days receiving KRT of any form between randomization and day 90
Interventions
DRUGJonosteril Infusionslösung
DRUGElektrolyt-Infusionslösung 153
Gesamtkationen/-anionen 153 mval/l
DRUGInfusionslösung zur intravenösen Anwendung
DRUGSODIUM HYDROGEN CARBONATE
DRUGSterofundin ISO Infusionslösung
DRUGRinger-Infusionslösung B. Braun
Sponsors
Universitaet Muenster
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Major adverse kidney events (MAKE90) Binary endpoint consisting of mortality or any KRT within 90 days after randomization or persistent renal dysfunction (creatinine value at day 90 ≥200% of baseline value) at day 90 | — |
Secondary
| Measure | Time frame |
|---|---|
| 90-day all-cause mortality (%), Elevation of the creatinine level to ≥200% of baseline value at day 90 (one measurement between day 80 and 120 after randomization), Receipt of any form of KRT within the 90-day time period after randomization, Kidney Replacement Therapy (KRT)-dependence at day 90 after randomization, KRT-free days, defined as difference between number of days alive and number of days receiving KRT of any form between randomization and day 90 | — |
Outcome results
None listed