Wilson's Disease
Conditions
Brief summary
The primary endpoint is the change in mean hepatic 64Cu standard uptake value (SUV) from pre- to post-intervention between the three groups.
Detailed description
Change in plasma zinc, total copper, exchangeable copper, and ceruloplasmin levels from pre- to post-intervention between the groups., Change in metallothionein (a protein related to homeostasis of e.g. zinc and copper) induction in peripheral blood mononuclear cells from pre- to post-intervention between the groups., Change in urinary zinc and copper levels from pre- to post-intervention between the groups., Number of AEs in the three groups.
Interventions
DRUGGalzin 50mg
DRUGET-700 75 mg
DRUGPlacebo
DRUGCOPPER (64CU) CHLORIDE
Sponsors
Region Midtjylland
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint is the change in mean hepatic 64Cu standard uptake value (SUV) from pre- to post-intervention between the three groups. | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in plasma zinc, total copper, exchangeable copper, and ceruloplasmin levels from pre- to post-intervention between the groups., Change in metallothionein (a protein related to homeostasis of e.g. zinc and copper) induction in peripheral blood mononuclear cells from pre- to post-intervention between the groups., Change in urinary zinc and copper levels from pre- to post-intervention between the groups., Number of AEs in the three groups. | — |
Outcome results
None listed