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Multicenter clinical trial on the effectiveness and safety of outpatient treatment of acute uncomplicated diverticulitis without antibiotics versus antibiotic treatment. ADIANA Trial.

Status
Not yet recruiting
Phases
Phase 4
Study type
Interventional
Source
EU CTIS
Registry ID
CTIS2025-523121-17-00
Enrollment
282
Registered
2026-04-30
Start date
Unknown
Completion date
Unknown
Last updated
2026-04-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diverticular disease of the intestine

Brief summary

Therapeutic failure rate (early, within ≤48 hours, and at one month) for both treatments (with and without antibiotics).

Detailed description

Results in terms of recurrence (number, type, and time to onset)., Time (days) until clinical recovery and return to daily social and work life., Risk factors for the development of diverticulitis and prognostic factors predictive of therapeutic failure and unfavorable progression to complicated acute diverticulitis, in general and according to treatment group, Quality of life and level of satisfaction with the care received in both groups

Interventions

DRUGamoxicilina/ácido clavulánico cinfa 875 mg/125 mg comprimidos recubiertos con película EFG
DRUGMEIACT 200 mg comprimidos recubiertos con película
DRUGcefuroxima cinfa 250 mg comprimidos recubiertos con película EFG
DRUGciprofloxacino cinfa 500 mg comprimidos recubiertos EFG

Sponsors

Fundacion Para La Formacion E Investigacion Sanitaria De La Region De Murcia
Lead SponsorOTHER

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Design outcomes

Primary

MeasureTime frame
Therapeutic failure rate (early, within ≤48 hours, and at one month) for both treatments (with and without antibiotics).

Secondary

MeasureTime frame
Results in terms of recurrence (number, type, and time to onset)., Time (days) until clinical recovery and return to daily social and work life., Risk factors for the development of diverticulitis and prognostic factors predictive of therapeutic failure and unfavorable progression to complicated acute diverticulitis, in general and according to treatment group, Quality of life and level of satisfaction with the care received in both groups

Outcome results

None listed

Source: EU CTIS · Data processed: May 1, 2026