Effect of Semaglutide on embryo quality in overweight and obese patients undergoing In Vitro Fertilization. A Randomized Controlled Trial

Conditions

Infertility

Brief summary

Number of good quality blastocysts

Detailed description

Days of stimulation, Total dose of Gonadotropins, Number Cumulus-oocyte complex (COCs), Number MII, Fertilization rate, Time of appearance of the 2nd polar body (tPB2), Time of pronuclei appearance (tPNa), Evaluation of both pronuclei (PN), Time of pronuclei disappearance (tPNf), Time of division from 2 to 8 cells (t2, t3, t4, t5, t6, t7, t8), Time of compaction (tSC), Time of morula (tM), Time of cavitation (tSB), Time of full blastulation (tB), Total number of day 5 blastocysts, Blastocyst formation rate, defined as the proportion of 2PN zygotes that reach the blastocyst stage, Number of embryos cryopreserved, Embryo stage (D5, D6, D7), Ovarian reserve markers (Antral Follicle Count,(AFC), Antimullerian Hormone (AMH)) before and after the treatment with semaglutide, Change in body weight and BMI, before and after the treatment with semaglutide, Change in WC, before and after the treatment with semaglutide

Related papers

No related papers found yet.

Interventions

DRUGWegovy 1 mg solution for injection in pre-filled pen

DRUGGanirelix Gedeon Richter 0.25 mg/0.5 mL solution for injection in pre-filled syringe

DRUGBemfola 300 IU/0.50 mL solution for injection in pre-filled pen

DRUGDecapeptyl diario 0

DRUG1 mg polvo y disolvente para solución inyectable

Eligibility

Sex/Gender

All

Age

18 Years to 64 Years

Design outcomes

Primary

Measure	Time frame
Number of good quality blastocysts	—

Secondary

Measure	Time frame
Days of stimulation, Total dose of Gonadotropins, Number Cumulus-oocyte complex (COCs), Number MII, Fertilization rate, Time of appearance of the 2nd polar body (tPB2), Time of pronuclei appearance (tPNa), Evaluation of both pronuclei (PN), Time of pronuclei disappearance (tPNf), Time of division from 2 to 8 cells (t2, t3, t4, t5, t6, t7, t8), Time of compaction (tSC), Time of morula (tM), Time of cavitation (tSB), Time of full blastulation (tB), Total number of day 5 blastocysts, Blastocyst formation rate, defined as the proportion of 2PN zygotes that reach the blastocyst stage, Number of embryos cryopreserved, Embryo stage (D5, D6, D7), Ovarian reserve markers (Antral Follicle Count,(AFC), Antimullerian Hormone (AMH)) before and after the treatment with semaglutide, Change in body weight and BMI, before and after the treatment with semaglutide, Change in WC, before and after the treatment with semaglutide	—

Measure

Time frame

Days of stimulation, Total dose of Gonadotropins, Number Cumulus-oocyte complex (COCs), Number MII, Fertilization rate, Time of appearance of the 2nd polar body (tPB2), Time of pronuclei appearance (tPNa), Evaluation of both pronuclei (PN), Time of pronuclei disappearance (tPNf), Time of division from 2 to 8 cells (t2, t3, t4, t5, t6, t7, t8), Time of compaction (tSC), Time of morula (tM), Time of cavitation (tSB), Time of full blastulation (tB), Total number of day 5 blastocysts, Blastocyst formation rate, defined as the proportion of 2PN zygotes that reach the blastocyst stage, Number of embryos cryopreserved, Embryo stage (D5, D6, D7), Ovarian reserve markers (Antral Follicle Count,(AFC), Antimullerian Hormone (AMH)) before and after the treatment with semaglutide, Change in body weight and BMI, before and after the treatment with semaglutide, Change in WC, before and after the treatment with semaglutide

—

Countries

Spain

Outcome results

None listed