(23026) A prospective, single-arm, Phase 4 study to evaluate the course of serum transthyretin (TTR) level with acoramidis in adult patients with variant or wild-type transthyretin amyloidosis with cardiomyopathy (ATTR-CM) previously treated with tafamidis.

Transthyretin Amyloid Cardiomyopathy (ATTR-CM)

Change in serum TTR level from baseline to month 6 or premature discontinuation of treatment

Serum TTR level at baseline, week 1, 2, 3, 4 and at month 3., Occurrence of TEAEs and type of TEAEs and serious TEAEs., Change from baseline to month 6 of NT-proBNP, hs-TnT, hs-CRP, RBP4., Signs of remodeling from baseline to month 6 in ECHO., Change from baseline to month 6 in 6MWD, Change from baseline to month 6 in kidney and thyroid biomarkers: eGFR, Creatinine, Cystatin C, UACR, and TSH., Change from baseline to month 6 in KCCQ-OS score and in EQ-5D-5L index score.

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