Pilot randomized controlled trial of the prevention of early respiratory tract infections in intubated patients. Comparison of the safety and efficacy of a short course of systemic antibiotic, a cough simulator and aspiration of subglottic secretions

cardiac arrest or other causes., Reduced level of consciousness associated with severe trauma, stroke, traumatic brain injury

Incidence of device (cough simulator and subglottic aspiration equipment), antibiotic and infection-related severe adverse events from inclusion to day 14, Incidence of respiratory tract infections (pneumonia and tracheobronchitis) in intubated critically ill patients from inclusion to day 14

Duration of intubation (days with endotracheal tube plus tracheostomy canula) at 90 days, Total days of respiratory support (expressed as days without invasive and non-invasive mechanical ventilation or high-flow nasal canula) at 90 days, Days of ICU-stay, Points of the modified Rankin score on day 90, Day 90 mortality, Days without receiving systemic antibiotic therapy on day 14, Percentage of positive bacterial cultures of respiratory samples during first 14 days, Type of bacterial isolates (Gram-negatives/positives, community/nosocomial) in respiratory samples at day 14, Bacterial resistance mechanisms identified in cultures (extended-spectrum betalactamases, carbapenemases and methicillin, vancomycin, linezolid resistance) in respiratory or any other location until day 14.), Percentage of subjects with bood-stained respiratory secretions, Number of daily catheter secretion suctioning sessions until day 14

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