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Obinutuzumab induced decreases of PLA2Rab in MN: a pilot study

Status
Not yet recruiting
Phases
Phase 2
Study type
Interventional
Source
EU CTIS
Registry ID
CTIS2025-521139-35-01
Acronym
2025-521139-35-01
Enrollment
20
Registered
2025-07-31
Start date
Unknown
Completion date
Unknown
Last updated
2025-07-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Primary membranous nephropathy

Brief summary

Disappearance rate (half-life) of anti-PLA2R antibodies.

Detailed description

Immunological remission defined as IFT negative., Efficacy on clinical disease activity, defined as either CR or PR at 12 months., Adverse events., Quality of life during obinutuzumab treatment.

Interventions

DRUGGazyvaro 1
DRUG000 mg concentrate for solution for infusion.

Sponsors

Radboud universitair medisch centrum Stichting
Lead SponsorOTHER

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Design outcomes

Primary

MeasureTime frame
Disappearance rate (half-life) of anti-PLA2R antibodies.

Secondary

MeasureTime frame
Immunological remission defined as IFT negative., Efficacy on clinical disease activity, defined as either CR or PR at 12 months., Adverse events., Quality of life during obinutuzumab treatment.

Countries

Netherlands

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 4, 2026