Effects of sodium-glucose cotransporter 2 inhibition on the mechanisms of heart failure with preserved ejection fraction

Conditions

Heart failure with preserved ejection fraction

Brief summary

Systolic properties derived from PV curve analysis: Maximum elastance, Diastolic properties derived from PV curve analysis: Relaxation, stiffness, equilibrium volume, elastic recoil

Detailed description

Reverse geometric remodeling variables of the LV: Ventricular volumes and mass measured by cardiac magnetic resonance imaging (MRI), Intraventricular flow patterns based on Doppler echocardiography and phase-contrast MRI: Vorticity parameters and blood transport into the LV; energy exchange between the myocardium and blood, Cardiomyocyte alterations: grade of hypertrophy assessed by morphometry and expression of pro-hypertrophic genes (atrial natriuretic peptide, sarcomeric proteins using real-time RT-PCR and western blot), Interstitial and perivascular fibrosis, Degree of collagen crosslinking, Microvascular alterations, Cardiomyocyte stiffness: Titin, Extracellular matrix: Lysyl-oxidases and hydroxylases, miR-19b, WISPER, and AGEs, Cardiomyocytes: NT-proBNP, high-sensitivity troponin T (TnT)

Related papers

No related papers found yet.

Interventions

DRUGForxiga 10 mg film-coated tablets

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Design outcomes

Primary

Measure	Time frame
Systolic properties derived from PV curve analysis: Maximum elastance, Diastolic properties derived from PV curve analysis: Relaxation, stiffness, equilibrium volume, elastic recoil	—

Secondary

Measure	Time frame
Reverse geometric remodeling variables of the LV: Ventricular volumes and mass measured by cardiac magnetic resonance imaging (MRI), Intraventricular flow patterns based on Doppler echocardiography and phase-contrast MRI: Vorticity parameters and blood transport into the LV; energy exchange between the myocardium and blood, Cardiomyocyte alterations: grade of hypertrophy assessed by morphometry and expression of pro-hypertrophic genes (atrial natriuretic peptide, sarcomeric proteins using real-time RT-PCR and western blot), Interstitial and perivascular fibrosis, Degree of collagen crosslinking, Microvascular alterations, Cardiomyocyte stiffness: Titin, Extracellular matrix: Lysyl-oxidases and hydroxylases, miR-19b, WISPER, and AGEs, Cardiomyocytes: NT-proBNP, high-sensitivity troponin T (TnT)	—

Measure

Time frame

Reverse geometric remodeling variables of the LV: Ventricular volumes and mass measured by cardiac magnetic resonance imaging (MRI), Intraventricular flow patterns based on Doppler echocardiography and phase-contrast MRI: Vorticity parameters and blood transport into the LV; energy exchange between the myocardium and blood, Cardiomyocyte alterations: grade of hypertrophy assessed by morphometry and expression of pro-hypertrophic genes (atrial natriuretic peptide, sarcomeric proteins using real-time RT-PCR and western blot), Interstitial and perivascular fibrosis, Degree of collagen crosslinking, Microvascular alterations, Cardiomyocyte stiffness: Titin, Extracellular matrix: Lysyl-oxidases and hydroxylases, miR-19b, WISPER, and AGEs, Cardiomyocytes: NT-proBNP, high-sensitivity troponin T (TnT)

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Countries

Spain

Outcome results

None listed